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Showing posts with label Statistics. Show all posts
Showing posts with label Statistics. Show all posts

Monday, October 31, 2016

Visual Analogue Scale & Statistical Concerns


🔸A frequently used tool in anaesthesia research is the 100 mm visual analogue scale (VAS). 

🔸This is most commonly used to measure postoperative pain, but can also be used to measure a diverse range of (mostly) subjective experiences such as preoperative anxiety, postoperative nausea, and patient satisfaction after ICU discharge. 

🔸Because there are infinite possible values that can occur throughout the range 0-100 mm, describing a continuum of pain intensity, most researchers treat the resulting data as continuous. 

🔸If there is some doubt about the sample distribution, then the data should be considered ordinal.

🔸When small numbers of observations are being analysed (say, less than 30 observations), it is preferable to consider VAS data as ordinal. 

🔸For a number of practical reasons, a VAS is sometimes converted to a 'verbal rating scale', whereby the subject is asked to rate an endpoint on a scale of 0-10 (or 0-5), most commonly recorded as whole numbers. In this situation it is preferable to treat the observations as ordinal data.

🔸There has been some controversy in the literature regarding which statistical tests should be used when analysing VAS data. 

🔸Mantha et al surveyed the anaesthetic literature and found that approximately 50% used parametric tests. 

🔸Dexter and Chestnuts used a multiple resampling (of VAS data) method to demonstrate that parametric tests had the greater power to detect differences among groups. 

🔸Myles et al have recently shown that the VAS has properties consistent with a linear scale, and thus VAS scores can be treated as ratio data. This supports the notion that a change in the VAS score represents a relative change in the magnitude of pain sensation. This enhances its clinical application.

Reference: Statistical Methods for Anaesthesia and Intensive Care, Paul S Myles and Tony Gin


Saturday, December 19, 2015

S͙U͙P͙E͙R͙I͙O͙R͙I͙T͙Y͙ A͙N͙D͙ E͙Q͙U͙I͙V͙A͙L͙E͙N͙C͙E͙ T͙R͙I͙A͙L͙S͙ ⬆️↔️


⬆️S͙U͙P͙E͙R͙I͙O͙R͙I͙T͙Y͙ T͙R͙I͙A͙L͙S͙

✔️Seek to establish that one treatment is better than another 

✔️The sample size is set so that there is high statistical power to detect a clinically meaningful difference between the two treatments 

↔️E͙Q͙U͙I͙V͙A͙L͙E͙N͙C͙E͙ T͙R͙I͙A͙L͙S͙

✔️Seek to test if a new treatment is similar  in effectiveness to an existing one

✔️Appropriate if the new treatment has certain benefits such as fewer side effects, being easier to use, or being cheaper 

✔️Designed to be able to demonstrate that, within given acceptable limits, the two treatments are equally effective 

✔️Equivalence is a pre-set maximum difference between treatments such that, if the observed difference is less than this, the two treatments are regarded as equivalent . The tighter the limits of equivalence are set, the larger the sample size that will be required 

✔️A serious condition requires tighter limits for equivalence than a less serious condition. 

✔️The calculated sample size tends to be bigger for equivalence trials than superiority trials 

🔴T͙H͙I͙N͙G͙S͙ T͙O͙ R͙E͙M͙E͙M͙B͙E͙R͙

👉🏿In general the design and implementation of equivalence trials is less straight forward than superiority trials 

👉🏿If patients are lost to follow-up or fail to comply with the trial protocol, then any differences between the treatments is likely to be reduced and so equivalence may be incorrectly inferred.

👉🏿So equivalence trials need very strict management and good patient follow-up to minimize these problems 

👉🏿It is often helpful to include a secondary analysis where subjects are analysed according to the treatment they actually received, ‘per protocol’ analysis 

#MedicalResearch ,#ClinicalResearch , #MedicalStatistics , #BioStatistics , #AnaesthesiaResearch , #Statistics ,#research

Reference: Oxford Handbook of Medical Statistics, Janet L. Peacock , Philip J. Peacock

Thursday, December 17, 2015

EXAMPLES OF RESEARCH QUESTIONS🔢



(From : Oxford Handbook of Medical Statistics, Janet L. Peacock, Philip J. Peacock, P:5)

❓What is the prevalence of diabetes mellitus in the population? 
🔴This is a simple descriptive study 

❓How effective is influenza vaccination in the community-based elderly? 
🔴This is a comparative study, comparing individuals who had vaccines with those who did not 

❓Does lowering blood pressure reduce the risk of coronary heart disease? 
🔴This is an evaluative study, investigating the effi cacy of lowering blood pressure 

❓Is prognosis following stroke dependent on age at the time of the event? 
🔴This is an observational study 

❓Why does smoking increase the risk of heart disease? 
🔴This is an explanatory study investigating the mechanism behind an observed relationship 

❓What evidence is there for the effectiveness of antidepressants in treating depression? 
🔴This study is a meta-analysis of existing interventional studies