Of patients who have SAH from ruptured aneurysm, 5% to 10% will have one or more first-order relatives who have also had a ruptured aneurysm.
The inheritance is probably dominant with variable penetrance.
Conditions associated with intracranial aneurysms include 〰〰〰〰〰〰〰〰〰〰〰〰〰〰〰〰〰
🏷polycystic kidney disease (5% of aneurysms series, 33% of polycystic kidney series)
🏷coarctation of the aorta (1% of aneurysm patients, 5% of coarctation patients, all of whom are hypertensive)
🏷sickle cell disease
🏷drug abuse (cocaine: generalized vasoconstriction and hypertension; intravenous use: mycotic aneurysms)
🏷hypertension (30% to 40% of patients with SAH).
Rarer associations
〰〰〰〰〰〰〰
🏷fibromuscular dysplasia
🏷Marfan's syndrome
🏷tuberous sclerosis
🏷Ehlers-Danlos syndrome
🏷hereditary hemorrhagic telangiectasia
🏷moyamoya disease
🏷pseudoxanthoma elasticum.
🏷Choriocarcinoma
🏷cardiac myxomas
Ref: Handbook of Neuroanesthesia, 4th Edition, p:144
