💧26 AA peptide hormone
💧synthesised from a prohormone in atrial secretory granules released in response to atrial stretch / wall tension
💧plasma half life, t ½ β ~ 3 mins
💧maximal natriuresis is less than that seen with frusemide
💧however ANF is ~ 100 times as potent
💧receptors are concentrated in cortical glomeruli
💧the postulated second messenger is cGMP ?
💧there is no direct effect upon Na + transport, or the Na + /K +-ATPase
💧neither amiloride nor prostaglandin inhibitors have an effect upon its actions
💧ANF effects include
🎯systemic vasodilatation ( mostly venodilation--> transient hypotension, decreases preload
🎯increases salt delivery to distal tubule
🎯decreases plasma renin
🎯decreases plasma aldosterone
🎯increases urinary excretion of Na, K, Ca, Mg, Phosphate, Chloride
🎯increases urine volume
No comments:
Post a Comment