⚜Furosemide is a loop diuretic
⚜It interferes with the concentrating capacity of the loop of Henle.
⚜It is effective in patients with renal dysfunction, whereas the thiazides are NOT.
⚜It potentiates the nephrotoxic effects of cephalosporins and the ototoxic effects of aminoglycosides.
⚜NSAIDs inhibit renal prostaglandin, causing sodium to be retained, which reduces the diuresis caused by furosemide.
⚜ Furosemide is a venous and arteriolar dilator and thus reduces both preload and afterload in a time frame just before the period of onset of a significant diuresis.
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