๐ปcreate an oncotic pressure difference that mobilises water across the blood–brain barrier through osmosis.
๐ปshrinks erythrocytes and makes them more deformable
๐ปincreases the calibre of the microcirculation by dehydrating vascular endothelium
๐ณ Advantages of Hypertonic Saline over mannitol:
๐ปless haemodynamic instability
๐ปless damage to the kidneys
๐ปeasier therapeutic monitoring through tracking serum sodium concentration.
๐ปless inclined to produce the late rise in ICP sometimes found with mannitol when it is deposited in the brain parenchyma.
๐ณ But no difference in survival between the two agents has been demonstrated.
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