๐ฅThe process of inflammation is maintained by 3 important mechanisms:
✔️Vasodilation
✔️Increased capillary permeability
✔️Migration of leucocytes
๐ฅWHO IS DOING THESE?
▪️PLASMA DERIVED MEDIATORS
✔️BRADYKININ --> Vasodilation & Increased capillary permeability
✔️COMPLEMENT MEDIATORS --> Mast cell degranulation --> Vasodilation & Increased capillary permeability + activate neutrophils and phagocyte migration
✔️COAGULATION: Forms a protective clot over the injured area
✔️ FIBRINOLYSIS: Activates neutrophils & macrophages by Fibrin Degradation Products (FDP)
▪️CELL DERIVED MEDIATORS
✔️HISTAMINE (from basophils and mast cells) --> Vasodilation & Increased capillary permeability
✔️LEUKOTRIENES (from basophils and mast cells) --> chemotaxis of granulocytes
Ⓜ️NEMO> " leukoTRYenes TRY to catch granulocytes"
✔️TUMOR NECROSIS FACTOR (cytokine from macrophage) --> activates endothelial cells , enhances phagocytosis
Ⓜ️NEMO> "TN(F)™ = F for 'Fagocytosis' TM= TNF is from Macrophages "
✔️CHEMOKINES are chemotactic #cytokines
✔️NITRIC OXIDE (from endothelial cells and macrophages) is a powerful vasodilator and smooth-muscle relaxant.
#anesthesia , #anaesthesia , #pathology , #exams , #MedicalStudents , #MedicalExams
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