CEREBRAL PHYSIOLOGY

A SORE STORY : THE PROPELLORS OF #INFLAMMATION

🔥The process of inflammation is maintained by 3 important mechanisms:

✔️Vasodilation 

✔️Increased capillary permeability 

✔️Migration of leucocytes

🔥WHO IS DOING THESE?

▪️PLASMA DERIVED MEDIATORS 

✔️BRADYKININ --> Vasodilation & Increased capillary permeability 

✔️COMPLEMENT MEDIATORS --> Mast cell degranulation --> Vasodilation & Increased capillary permeability + activate neutrophils and phagocyte migration 

✔️COAGULATION: Forms a protective clot over the injured area

✔️ FIBRINOLYSIS: Activates neutrophils & macrophages by Fibrin Degradation Products (FDP)

▪️CELL DERIVED MEDIATORS

✔️HISTAMINE (from basophils and mast cells) --> Vasodilation & Increased capillary permeability 

✔️LEUKOTRIENES (from basophils and mast cells) --> chemotaxis of granulocytes 

Ⓜ️NEMO> " leukoTRYenes TRY to catch granulocytes"

✔️TUMOR NECROSIS FACTOR (cytokine from macrophage) --> activates endothelial cells , enhances phagocytosis 

Ⓜ️NEMO> "TN(F)™ = F for 'Fagocytosis' TM= TNF is from Macrophages "

✔️CHEMOKINES are chemotactic #cytokines

✔️NITRIC OXIDE (from endothelial cells and macrophages) is a powerful vasodilator and smooth-muscle relaxant.

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