Morphine and Hydromorphone

• Morhine is metabolised via hepatic system and excreted by renal system
• It can get accumulated in hepatic/renal dysfunction and obesity
• Morphine has 2 metabolites:
• Morphine 6 glucoronide- Active metabolite: responsible for analgesia and sedation
• Morphine 3 glucoronide: Can cause seizures
• Morphine has histamine releasing property
• Hydromorphone is more potent than morphine
• Hydromorphone doesnt have active metabolites
• Hydromorphone lacks histamine release