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Friday, April 1, 2016

Risk for Occupational Transmission of HCV



⚠️HCV is not transmitted efficiently through occupational exposures to blood. 

⚠️The average incidence of anti-HCV seroconversion after accidental percutaneous exposure from an HCV-positive source is 1.8% (range: 0%–7%) 

⚠️Transmission rarely occurs from mucous membrane exposures to blood, and no transmission in health care professionals, has been documented from intact or nonintact skin exposures to blood 

⚠️ Environmental contamination with blood containing HCV is not a significant risk for transmission in the health-care setting with the possible exception of the hemodialysis setting where HCV transmission related to environmental contamination and poor infection-control practices have been implicated 

⚠️The risk for transmission from exposure to fluids or tissues other than HCV-infected blood also has not been quantified but is expected to be low.

Reference: Centre for Disease Control June 29, 2001 / Vol. 50 / No. RR-11, Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposuresto HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis


NEUROTOXICITY OF ANESTHETIC AGENTS IN LONG-TERM


๐Ÿ”นHalothane and Isoflurane: Amyloidogenic properties

๐Ÿ”นIsoflurane : Behavioural changes, apoptosis (Sevo lacks this)

๐Ÿ”นNitrous oxide: Dose dependent and paradoxical protective and neurotoxic effects 

๐Ÿ”นOpioids @ moderate to high dose: Brain hyper metabolism and damage; Remifentanil doubtful role in genesis of Alzheimer's disease

(Acta Rad, CJA, Proct Natl Acad Sci, Anesth, Lancet)