NEUROTOXICITY OF ANESTHETIC AGENTS IN LONG-TERM

🔹Halothane and Isoflurane: Amyloidogenic properties

🔹Isoflurane : Behavioural changes, apoptosis (Sevo lacks this)

🔹Nitrous oxide: Dose dependent and paradoxical protective and neurotoxic effects 

🔹Opioids @ moderate to high dose: Brain hyper metabolism and damage; Remifentanil doubtful role in genesis of Alzheimer's disease

(Acta Rad, CJA, Proct Natl Acad Sci, Anesth, Lancet)