- Morhine is metabolised via hepatic system and excreted by renal system
- It can get accumulated in hepatic/renal dysfunction and obesity
- Morphine has 2 metabolites:
- Morphine 6 glucoronide- Active metabolite: responsible for analgesia and sedation
- Morphine 3 glucoronide: Can cause seizures
- Morphine has histamine releasing property
- Hydromorphone is more potent than morphine
- Hydromorphone doesnt have active metabolites
- Hydromorphone lacks histamine release
Wednesday, May 23, 2018
Morphine and Hydromorphone
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