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Wednesday, November 2, 2016

Succinylcholine aka Suxamethonium


 ⚗️Two molecules of acetyl choline joined together by the acetyl group forms Succinylcholine 

⚗️ It can be presented as chloride, bromide or iodide salt

⚗️ When presented as the chloride salt, it's a solution with concentration 50 mg/ mL

⚗️ When presented as bromide or iodide salts, they are powders, with more stability, shell life and suited for warm climates; but has to be reconstituted before use

⚗️ pH of the solution is around 4

⚗️ So they are destroyed by mixing it with alkaline solutions (e.g. Thiopentone )

Reference: Kestin I. Suxamethonium. Update in Anaesthesia 1992; 1: article 7.  Peck T, Hill S, Williams M. Pharmacology for Anaesthesia and Intensive Care, 3rd edn. Cambridge: Cambridge University Press, 2008; pp. 179–84 .

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