NALOXONE DOSAGE

DOSAGE: IV: For  reversal  of  post-operative  respiratory  depression  and  coma:    20-40mcg  IV  PRN 

For  opioid  overdose:    40-400mcg  IV  PRN 

Infusion:    If  an  infusion  is  required,  commence  the  infusion  with  an  hourly  infusion  rate calculated  as  2/3rd  of  the  total  bolus  dose  given  to  achieve  the  desired  opioid  reversal effect 

DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY:   Dose  as  in  normal  renal  function    

 DOSAGE  IN  PAEDIATRICS: IV: For  post-operative  respiratory  depression  or  over-sedation,  give  0.002mg/kg/dose  (i.e. dilute  0.4mg  to  20ml  and  then  give  0.1ml/kg/dose).    Repeat  every  2  minutes  x4  if required,  then  commence  infusion  by  adding  0.3mg/kg  to  30ml  5%  dextrose  and running  at  0-1ml/hr  (0.01mg/kg/hr).   For  opiate  overdose,  give  0.01mg/kg  (max  0.4mg)  (i.e.  dilute  0.4mg  to  10ml  and  give 0.25ml/kg/dose).    Repeat  every  2  minutes  x4  if  required,  then  commence  infusion  by adding  0.3mg/kg  to  30ml  5%  dextrose  and  running  at  0-1ml/hr  (0.01mg/kg/hr