LAB et al.....(Started working).....LOL😆😆😆😆 labetalol SAGA

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💉Comes as 5  mg/mL  ampoules 

💉Infusion:  200 mg/200  mL 

     Add  200mg  [40  mL]  labetalol  to  160  mL  D5W,      NS,  LR,  or  D5/NS 

     Final  concentration:  1  mg/mL 

💉Blocks  α,  β1,  and  β2  adrenergic  receptor  sites.    

💉Decreases  heart  rate  and  peripheral  vascular  resistance.  

💉Ratio  of  alpha-‐  to  beta-‐ blockade  depends  upon  the  route  of  administration  (1:3  oral  versus  1:7  IV)  

💉Onset  of  action:  2-‐ 5  minutes  

💉Duration:  2-‐ 4  hours

💉IV  Bolus:  20  mg  over  at  least  2  minutes  as  initial  dose, may  repeat  with  doses  of  40-‐ 80  mg  q10min; Do  not  exceed  total  dose of 300 mg 

💉 Infusion:  starting  2  mg/min  (2  mL/min)  –  8  mg/min  titrated  to  response.   Do  not  exceed  total  dose  of  300

💉As  cumulative  dose  nears  300mg  IV,  duration  of  action  extends  to  nearly  18  hours.

🙀-NEW INSIGHTS: 

Antihypertensive drugs methyldopa, labetalol, hydralazine, and clonidine improve trophoblast interaction with endothelial cellular networks in vitro

B Xu, F Charlton, A Makris, A Hennessy - Journal of hypertension, 2014 

#anesthesia , #GDM , #PIH , #anaesthesia